Acute Fluoxetine Treatment Produce Anxiolytic Effects without Modulating Behaviour Response on Exposure to Forced Swimming Test
نویسندگان
چکیده
منابع مشابه
Chronic treatment with fluoxetine and sertraline prevents forced swimming test-induced hypercontractility of rat detrusor muscle.
Serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors represent important targets for the development of new treatments for detrusor overactivity and urinary incontinence. The present study was undertaken to investigate the effects of the forced swimming test (FST) on the contractile response of isolated rat detrusor muscle and to examine the effects of in vivo treatments of fluoxetine and ...
متن کاملAntidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test.
PURPOSE To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS Rats given injections of fluoxetine displayed significantly less immobility (...
متن کاملInteraction between the forced swimming test and fluoxetine treatment on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat.
We used in vivo microdialysis to examine extracellular levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the striatum and the lateral septum during the forced swimming test, (FST) a behavioral test conducted in rats that is commonly used to predict the effect of antidepressant drugs. The forced swimming test consisted of a 15-min pretest swim and a 5-min test swim ...
متن کاملEffect of co-administration of fluoxetine and amantadine on immunoendocrine parameters in rats subjected to a forced swimming test.
Considerable attention has been paid to a possible role of immunological dysregulation in the pathogenesis of depression. It has been reported that combined administration of antidepressant drugs and the non-competitive NMDA receptor antagonist amantadine reduces immobility time in the forced swimming test (FST). Moreover, preliminary clinical data show that such a combination of drugs has a be...
متن کاملAnxiolytic effects of fluoxetine and nicotine exposure on exploratory behavior in zebrafish
Zebrafish (Danio rerio) have emerged as a popular model for studying the pharmacology and behavior of anxiety. While there have been numerous studies documenting the anxiolytic and anxiogenic effects of common drugs in zebrafish, many do not report or test for behavioral differences between the sexes. Previous studies have indicated that males and females differ in their baseline level of anxie...
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ژورنال
عنوان ژورنال: Saudi Journal of Medical and Pharmaceutical Sciences
سال: 2019
ISSN: 2413-4929,2413-4910
DOI: 10.36348/sjmps.2019.v05i09.008